Public health policymakers face significant challenges in addressing the interests of large economic conglomerates that produce unhealthy products such as tobacco, alcohol, and ultra-processed foods and beverages. These corporations often have significant political influence and use various strategies to avoid regulations that would reduce their profits. The article highlights the importance of identifying and analyzing conflicts of interest to safeguard public health and notes that Brazil stands out as a reference in social participation and control in relation to food and nutrition policies. However, established participatory bodies have not been sufficient to avoid the deleterious political influence of agribusiness and big food companies. The article argues that active social control coupled with partnerships with universities and structured national councils are needed to defend public health policies. Additionally, intersectoral public policies that promote sustainable agriculture and nutritious food production while protecting the environment are essential. In conclusion, policymakers must prioritize the well-being of citizens and the environment over corporate interests through a democratic approach to public health policy-making. By strengthening civil society organizations and promoting active social control, policymakers can better address these challenges and promote sustainable food systems that support public health and environmental sustainability.